Dr Andrew Horne

 Andrew HorneJob Title:
Senior Lecturer and Consultant Gynaecologist

Contact Details:
Telephone: 0131 242 6988/2525  Email: andrew.horne@ed.ac.uk  Room: C1.03

Please note I cannot respond to clinical enquiries via my university email.  

For all clinical enquiries, please contact my secretary Fiona Elliott on 0131 242 2525 or by email at fiona.elliot@nhslothian.scot.nhs.uk.

Research Interests

Front cover Figure 1 AWHorne

Grants

HTA (£1,962,989) 2014-19 “PRISM: Effectiveness of progesterone to prevent miscarriage in women with early pregnancy bleeding: A placebo-controlled randomised trial” A Coomaraswamy (PI), AW Horne, C Overton, C Bottomley, W Duncan, D Jurkovic,D Feroza, H Harb, J Daniels, J Norman, K Hinshaw, L Middleton, MA Lumsden, N Raine-Fenning, R Farquharson, R Bender-Atik, S Quenby, T Bourne, T Roberts

HTA (£2,487,834) 2013-18 “PRE-EMPT: Preventing Recurrence of Endometriosis by Means of long acting Protestogen Therapy” S Bhattacharya (PI), K Cooper, J Gupta, J Daniels, J Clark, E Denny, E Saridogan, L Middleton, G Jones, AW Horne, C Becker

MRC Centenary Award (£99,314) 2012-14

Chief Scientist Office (£117,758) 2013-15 “Long term health of women diagnosed with endometriosis: a Scottish record linkage study” S Bhattacharya (PI), K Cooper, L Saraswat, S Bhattacharya, D Ayansina, AW Horne, D Miligkos

Wellbeing of Women (£144,337) 2012-14 “Towards new treatments for endometriosis: is the peritoneal transforming growth factor-β superfamily a therapeutic target?” AW Horne (PI), WC Duncan, JK Brown, HO Critchley, A McNeilly, PTK Saunders

Chief Scientist Office (£261,605) 2012-14 “A pilot randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women” AW Horne (PI), S Bhattacharya, HO Critchley, J Wilson, O Wu, S Jack, M Porter, S Lewis

MRC Clinician Scientist Fellowship (£1,228,184) 2009-14 “Improving women’s health and pregnancy outcome: understanding the aetiology of ectopic pregnancy”

Key recent publications

Greaves E, Grieve K, Horne AW, Saunders PT. Elevated peritoneal expression and estrogen regulation of nociceptive ion channels in endometriosis. J Clin Endocrinol Metab 2014 jc20142282.

Young VJ, Brown JK, Maybin J, Saunders PT, Duncan WC, Horne AW. Transforming growth factor-β induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis. J Clin Endocrinol Metab 2014 jc20141026.

Horne AW, Brown JK, Nio-Kobayashi J, Abidin HBZ, Adin ZEHA, Boswell L, Burgess S, Lee CF, Duncan WC. The association between smoking and ectopic pregnancy: why nicotine is BAD for your Fallopian tube. PLoS One 2014 20;9(2):e89400

Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D’Hooghe T, De Bie B, Heikinheimo O, Horne AW, Kiesel L, Nap A, Prentice A, Saridogan E, Soriano D, Nelen W. ESHRE guideline: management of women with endometriosis. Hum Reprod 2014 29(3):400-12

Nilsson UW, Johns TG, Wilmann T, Kaitu’u-Lino T, Whitehead C, Dimitriadis E, Menkhorst E, Saglam B, Gao Y, Greenall SA, Horne AW, Tong S. Effects of Gefinitb, an Epidermal Growth Factor Receptor Inhibitor, on Human Placental Cell Growth. Obstet Gynecol 2013 122(4):745-51

Skubisz MM, Horne AW, Johns TG, Nilsson UW, Duncan WC, Wallace EM, Critchley HOD, Tong S. Combination Gefitinib and Methotrexate Compared with Methotrexate Alone to Treat Ectopic Pregnancy. Obstet Gynecol 2013 122(4):737-44

Reactions in the press:

http://www.dailymail.co.uk/health/article-2416424/Lung-cancer-drug-Gefitinib-protect-fertility-ectopic-pregnancy.html

http://www.scotsman.com/news/health/cancer-drug-could-help-ectopic-pregnancy-women-1-3084018

http://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-24021956

Brown JK, Lauer KB, Ironmonger EL, Inglis NF, Bourne TH, Critchley HO, Horne AW. Shotgun proteomics identifies serum fibronectin as a candidate diagnostic biomarker for inclusion in future multiplex tests for ectopic pregnancy. PLoS One 2013 8(6):e66974

Skubisz MM, Brown JK, Tong S, Kaitu’u-Lino T, Horne AW. Serum Macrophage Inhibitory Cytokine-1 as a Biomarker for Ectopic Pregnancy in Women with a Pregnancy of Unknown Location. PLoS One 2013 8:6 e66339

Young VJ, Brown JK, Saunders PT, Horne AW. The role of the peritoneum in the pathogenesis of endometriosis. Hum Reprod Update 2013 2013 19(5):558-69

Staff/group members

  • Jean Wade (research technician)
  • Vicky Young (research technician)
  • Ann Doust (clinical trial coordinator)
  • Helen Dewart (clinical research nurse)
  • Sevasti Giakoumelou (PhD Student)

Principal collaborators

University of Edinburgh:

  • Hilary Critchley (CRH)
  • Colin Duncan (CRH)
  • Philippa Saunders (CRH)
  • Sarah Howie (CIR)
  • Gary Entrican (Moredun Research Institute)

National/international:

  • Siladitya Bhattacharya (Aberdeen University)
  • Olivia Wu (University of Glasgow)
  • Tom Bourne (Imperial College London)
  • Katy Vincent (University of Oxford)
  • Jane Daniels (University of Birmingham)
  • Stephen Tong (University of Monash Melbourne)

Responsibilities

  • Deputy Coordinator of ESHRE SIGEE
  • Member of RCOG Scientific Advisory Committee
  • Member of RCOG Scottish Committee
  • Member of ESHRE Endometriosis Guideline Group
  • Member of Wellbeing of Women Research Advisory Committee
  • Trustee and Medical Advisor to the Ectopic Pregnancy Trust
  • Medical Advisor to Endometriosis UK
  • Medical Advisor to Pelvic Pain Support Network
  • Associate Editor for Molecular Human Reproduction and PLoS One
  • Member of RCOG Early Pregnancy Clinical Studies Group

Book chapters

Che Bakri NA, Busby-Earle C, Steel R, Horne AW. ‘Pelvic and Reproductive System Symptoms’ In ABC of Medically Unexplained Symptoms. Ed Burton. Wiley-Blackwell 2013 ISBN: 978-1-119-96725-5.

Svingalam V, Wilson J, Horne AW. ‘Novel pain relief agents in endometriosis’ In World Clinics Obstetrics and Gynaecology. Eds Bhattacharya, Arora. Jaypee Brothers Medical Publishers (P) Ltd (in press).

Horne AW, Critchley HOD. ‘Medical Therapies for Pain – Progestins’ In Endometriosis: Science and Practice. Eds Giudice, Evers, Healy. Wiley-Blackwell 2012 ISBN: 978-1-4443-3213-1.

Horne AW, Critchley HOD. ‘Menstrual Disorders’. In Dewhurst’s 8th Edition. Ed Edmonds. Wiley-Blackwell 2012 ISBN: 978-0-470-65457-6.

Horne AW, Ford CM. ‘The normal menstrual cycle’ and Horne AW, ‘Disorders of the menstrual cycle’. In Gynaecology by Ten Teachers, 19th Edition. Hodder Arnold Health Sciences 2011 ISBN: 978-0-340-983-546.

Munro KI, Horne AW, Critchley HOD. Amenorrhoea, oligomenorrhoea and hypogonadal-pituitary function. In Gynaecology, 4th Edition. Eds Shaw, Luesly, Monga. Churchill Livingston 2010 ISBN: 978-0-7020-3120-5.

Maybin J, Horne AW, Critchley HOD. ‘Menstrual Disorders’ and ‘Benign Gynaecological Disorders’. In Training in Obstetrics and Gynaecology; the essential curriculum, 1st Edition. Eds Sarris, Saxena, Bewley. Oxford University Press 2009 ISBN 978-0-19-921847-9.

Updated 19 April, 2014