Telephone: 0131 242 6796/22694
Please note I cannot respond to clinical enquiries via my university email. For all clinical enquiries, please contact my secretary Fiona Elliott on 0131 242 2525 or by email at email@example.com.
BASIC SCIENCE STUDIES: Understanding of Fallopian tube, endometrial and peritoneal biology
CLINICAL STUDIES: Biomarkers and novel medical treatments for ectopic pregnancy; diagnosis and management of endometriosis and chronic pelvic pain www.crh.ed.ac.uk/pelvicpain
Current research projects
- Improving women’s health and pregnancy outcome: understanding the aetiology of ectopic pregnancy
- Diagnostic biomarker development for ectopic pregnancy
- GEM’ Combination gefitinib and methotrexate to treat ectopic pregnancies: Phase I-II clinical trial
- Understanding the role of TGF-beta superfamily and its target genes in the aetiology of endometriosis
- The prevalence of neuropathic pain in women with chronic pelvic pain
- ‘GaPP’ Gabapentin for the management of chronic pelvic pain: multi-centre pilot randomised controlled trial
HTA (£2,487,834) 2013-18 “PRE-EMPT: Preventing Recurrence of Endometriosis by Means of long acting Protestogen Therapy” S Bhattacharya (PI), K Cooper, J Gupta, J Daniels, J Clark, E Denny, E Saridogan, L Middleton, G Jones, AW Horne, C Becker
MRC Centenary Award (£99,314) 2012-13
Chief Scientist Office (£117,758) 2013-15 “Long term health of women diagnosed with endometriosis: a Scottish record linkage study” S Bhattacharya (PI), K Cooper, L Saraswat, S Bhattacharya, D Ayansina, AW Horne, D Miligkos
Wellbeing of Women (£144,337) 2012-14 “Towards new treatments for endometriosis: is the peritoneal transforming growth factor-β superfamily a therapeutic target?” AW Horne (PI), WC Duncan, JK Brown, HO Critchley, A McNeilly, PTK Saunders
Chief Scientist Office (£261,605) 2012-14 “A pilot randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women” AW Horne (PI), S Bhattacharya, HO Critchley, J Wilson, O Wu, S Jack, M Porter, S Lewis
Monash Institute of Medical Research (£62,363) 2010-12 “Combination gefitinib and methotrexate to treat ectopic pregnancies: Phase I-II clinical trial” S Tong (PI), AW Horne, HOD Critchley
MRC Clinician Scientist Fellowship (£1,228,184) 2009-13 “Improving women’s health and pregnancy outcome: understanding the aetiology of ectopic pregnancy”
Key recent publications
Nilsson UW, Johns TG, Wilmann T, Kaitu’u-Lino T, Whitehead C, Dimitriadis E, Menkhorst E, Saglam B, Gao Y, Greenall SA, Horne AW, Tong S. Effects of Gefinitb, an Epidermal Growth Factor Receptor Inhibitor, on Human Placental Cell Growth. Obstetrics and Gynecology, in press.
Reactions in the press:
Skubisz MM, Horne AW, Johns TG, Nilsson UW, Duncan WC, Wallace EM, Critchley HOD, Tong S. Combination Gefitinib and Methotrexate Compared with Methotrexate Alone to Treat Ectopic Pregnancy. Obstetrics and Gynecology, in press.
Horne AW, Skubisz MM, Doust A, Duncan WC, Wallace E, Critchley HO, Johns TG, Norman JE, Bhattacharya S, Mollison J, Rassmusen M, Tong S. Phase II single arm open label multicentre clinical trial to evaluate the efficacy and side effects of a combination of gefitinib and methotrexate to treat tubal ectopic pregnancies (GEM II): study protocol. BMJ Open 2013 3(7) e002902
Brown JK, Lauer KB, Ironmonger EL, Inglis NF, Bourne TH, Critchley HO, Horne AW. Shotgun proteomics identifies serum fibronectin as a candidate diagnostic biomarker for inclusion in future multiplex tests for ectopic pregnancy. PLoS One 2013 8(6):e66974
Skubisz MM, Brown JK, Tong S, Kaitu’u-Lino T, Horne AW. Serum Macrophage Inhibitory Cytokine-1 as a Biomarker for Ectopic Pregnancy in Women with a Pregnancy of Unknown Location. PLoS One 2013 8:6 e66339
Jowicz AP, Brown JK, McDonald SE, Shaw JL, Critchley HO, Horne AW. Characterization of the Temporal and Spatial Expression of a Disintegrin and Metalloprotease 17 in the Human Endometrium and Fallopian Tube. Reprod Sci 2013 [Epub ahead of print]
Young VJ, Brown JK, Saunders PT, Horne AW. The role of the peritoneum in the pathogenesis of endometriosis. Hum Reprod Update 2013 [Epub ahead of print]
Horne AW, Critchley HO, Doust A, Fehr D, Wilson J, Wu O, Jack S, Porter M, Lewis S, Bhattacharya S. GaPP: a pilot randomised controlled trial of the efficacy of action of gabapentin for the management of chronic pelvic pain in women: study protocol. BMJ Open 2012 2(3) pii: e001297
Brown JK, Shaw JL, Critchley HOD, Horne AW. Human Fallopian tube epithelium constitutively expresses integrin endometrial receptivity markers: no evidence for a tubal implantation window. Mol Hum Rep 2012 18(3):111-20.
Jeremy Brown (post-doctoral scientist)
Jean Wade (research technician)
Ann Doust (clinical trial coordinator)
Helen Dewart (clinical research nurse)
Vicky Young (PhD Student)
Sevasti Giakoumelou (PhD Student)
University of Edinburgh:
Hilary Critchley (CRH)
Colin Duncan (CRH)
Philippa Saunders (CRH)
Fiona Denison (CRH)
Sarah Howie (CIR)
Gary Entrican (Moredun Research Institute)
Siladitya Bhattacharya (Aberdeen University)
Olivia Wu (University of Glasgow)
Paddy Horner (University of Bristol)
Tom Bourne (Imperial College London)
Stephen Tong (University of Monash Melbourne)
SK Dey (Cincinnati Children’s Hospital Medical Center USA)
Deputy Coordinator of ESHRE SIGEE
Member of RCOG Scientific Advisory Committee
Member of RCOG Scottish Committee
Member of ESHRE Endometriosis Guideline Group
Member of Wellbeing of Women Research Advisory Committee
Trustee and Medical Advisor to the Ectopic Pregnancy Trust
Medical Advisor to Pelvic Pain Support Network
Associate Editor for Journal of Family Planning and Reproductive Health Care, BMC Pregnancy and Childbirth and BioMed Research International
Member of RCOG Early Pregnancy Clinical Studies Group
Che Bakri NA, Busby-Earle C, Steel R, Horne AW. ‘Pelvic and Reproductive System Symptoms’ In ABC of Medically Unexplained Symptoms. Ed Burton. Wiley-Blackwell 2013 ISBN: 978-1-119-96725-5.
Svingalam V, Wilson J, Horne AW. ‘Novel pain relief agents in endometriosis’ In World Clinics Obstetrics and Gynaecology. Eds Bhattacharya, Arora. Jaypee Brothers Medical Publishers (P) Ltd (in press).
Horne AW, Critchley HOD. ‘Medical Therapies for Pain – Progestins’ In Endometriosis: Science and Practice. Eds Giudice, Evers, Healy. Wiley-Blackwell 2012 ISBN: 978-1-4443-3213-1.
Horne AW, Critchley HOD. ‘Menstrual Disorders’. In Dewhurst’s 8th Edition. Ed Edmonds. Wiley-Blackwell 2012 ISBN: 978-0-470-65457-6.
Horne AW, Ford CM. ‘The normal menstrual cycle’ and Horne AW, ‘Disorders of the menstrual cycle’. In Gynaecology by Ten Teachers, 19th Edition. Hodder Arnold Health Sciences 2011 ISBN: 978-0-340-983-546.
Munro KI, Horne AW, Critchley HOD. Amenorrhoea, oligomenorrhoea and hypogonadal-pituitary function. In Gynaecology, 4th Edition. Eds Shaw, Luesly, Monga. Churchill Livingston 2010 ISBN: 978-0-7020-3120-5.
Maybin J, Horne AW, Critchley HOD. ‘Menstrual Disorders’ and ‘Benign Gynaecological Disorders’. In Training in Obstetrics and Gynaecology; the essential curriculum, 1st Edition. Eds Sarris, Saxena, Bewley. Oxford University Press 2009 ISBN 978-0-19-921847-9.