Job Title
Senior Clinical Lecturer and Consultant Gynaecologist
Contact Details
Telephone: 0131 242 6609/9427/2525
Email: andrew.horne@ed.ac.uk
Research Interests
BASIC SCIENCE STUDIES: Understanding of Fallopian tube, endometrial and peritoneal biology
CLINICAL STUDIES: Biomarkers and novel medical treatments for ectopic pregnancy; diagnosis and management of endometriosis and chronic pelvic pain www.crh.ed.ac.uk/pelvicpain
Current research projects
- Improving women’s health and pregnancy outcome: understanding the aetiology of ectopic pregnancy
- Diagnostic biomarker development for ectopic pregnancy
- GEM’ Combination gefitinib and methotrexate to treat ectopic pregnancies: Phase I-II clinical trial
- Understanding the role of TGF-beta superfamily and its target genes in the aetiology of endometriosis
- The prevalence of neuropathic pain in women with chronic pelvic pain
- ‘GaPP’ Gabapentin for the management of chronic pelvic pain: multi-centre pilot randomised controlled trial
Grants
MRC Centenary Award (£99,314) 2012-13
Chief Scientist Office (£117,758) 2013-15 “Long term health of women diagnosed with endometriosis: a Scottish record linkage study” S Bhattacharya (PI), K Cooper, L Saraswat, S Bhattacharya, D Ayansina, AW Horne, D Miligkos
Wellbeing of Women (£144,337) 2012-14 “Towards new treatments for endometriosis: is the peritoneal transforming growth factor-β superfamily a therapeutic target?” AW Horne (PI), WC Duncan, JK Brown, HO Critchley, A McNeilly, PTK Saunders
Chief Scientist Office (£261,605) 2012-14 “A pilot randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women” AW Horne (PI), S Bhattacharya, HO Critchley, J Wilson, O Wu, S Jack, M Porter, S Lewis
Monash Institute of Medical Research (£62,363) 2010-12 “Combination gefitinib and methotrexate to treat ectopic pregnancies: Phase I-II clinical trial” S Tong (PI), AW Horne, HOD Critchley
MRC Clinician Scientist Fellowship (£1,228,184) 2009-13 “Improving women’s health and pregnancy outcome: understanding the aetiology of ectopic pregnancy”
Key recent publications
Horne AW, Brown JK, Tong S, Kaitu’u-Lino T. ADAM-12 as a biomarker of ectopic pregnancy. PLoS One 2012 7(8):e41442.
Horne AW, Critchley HO, Doust A, Fehr D, Wilson J, Wu O, Jack S, Porter M, Lewis S, Bhattacharya S. GaPP: a pilot randomised controlled trial of the efficacy of action of gabapentin for the management of chronic pelvic pain in women: study protocol. BMJ Open. 2012 2(3). pii: e001297.
Brown JK, Shaw JL, Critchley HOD, Horne AW. Human Fallopian tube epithelium constitutively expresses integrin endometrial receptivity markers: no evidence for a tubal implantation window. Mol Hum Rep 2012 18(3):111-20.
Duncan WC, Shaw JL, Burgess S, McDonald SE, Critchley HO, Horne AW. Ectopic pregnancy as a model to identify endometrial genes and signaling pathways important in decidualization and regulated by local trophoblast. PLoS One. 2011;6(8):e23595.
Shaw, JLV, Wills GS, Kai-Fai Lee, Horner PJ, McClure MO, Abrahams VM, Jabbour HN, Critchley, HOD, Entrican G, Horne AW. Chlamydia trachomatis infection increases Fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy. Am J Pathol 2011 178(1):253-60.
Horne AW, Shaw JL, Murdoch A, McDonald SE, Williams AR, Jabbour HN, Duncan WC, Critchley HO. Placental Growth Factor: A Promising Diagnostic Biomarker for Tubal Ectopic Pregnancy. J Clin Endocrinol Metab 2011 96(1):E104-8.
Staff/group members
Jeremy Brown (post-doctoral scientist)
Jean Wade (research technician)
Ann Doust (clinical trial coordinator)
Helen Dewart (clinical research nurse)
Vicky Young (PhD Student)
Sevasti Giakoumelou (PhD Student)
Hajah Hanisah Haji Sharif (Brunei Discovery Year Student)
Principal collaborators
University of Edinburgh:
Hilary Critchley (CRH)
Colin Duncan (CRH)
Philippa Saunders (CRH)
Fiona Denison (CRH)
Sarah Howie (CIR)
Pam Warner (Centre for Population Health Sciences)
Gary Entrican (Moredun Research Institute)
National/international:
Siladitya Bhattacharya (Aberdeen University)
Paul Fowler (Aberdeen University)
Olivia Wu (University of Glasgow)
Paddy Horner (University of Bristol)
Tom Bourne (Imperial College London)
Stephen Tong (University of Monash Melbourne)
SK Dey (Cincinnati Children’s Hospital Medical Center USA)
Responsibilities
Deputy Coordinator of ESHRE SIGEE
Member of RCOG Scientific Advisory Committee
Member of RCOG Scottish Committee
Member of ESHRE Endometriosis Guideline Group
Member of Wellbeing of Women Research Advisory Committee
Medical Advisor to the Ectopic Pregnancy Trust
Associate Editor for Journal of Family Planning and Reproductive Health Care, BMC Pregnancy and Childbirth and BioMed Research International
Member of RCOG Early Pregnancy Clinical Studies Group
Associate Member of Faculty of 1000 Medicine
Book chapters
Svingalam V, Wilson J, Horne AW. ‘Novel pain relief agents in endometriosis’ In World Clinics Obstetrics and Gynaecology. Eds Bhattacharya, Arora. Jaypee Brothers Medical Publishers (P) Ltd (in press).
Horne AW, Critchley HOD. ‘Medical Therapies for Pain – Progestins’ In Endometriosis: Science and Practice. Eds Giudice, Evers, Healy. Wiley-Blackwell 2012 ISBN: 978-1-4443-3213-1.
Horne AW, Critchley HOD. ‘Menstrual Disorders’. In Dewhurst’s 8th Edition. Ed Edmonds. Wiley-Blackwell 2012 ISBN: 978-0-470-65457-6.
Horne AW, Ford CM. ‘The normal menstrual cycle’ and Horne AW, ‘Disorders of the menstrual cycle’. In Gynaecology by Ten Teachers, 19th Edition. Hodder Arnold Health Sciences 2011 ISBN: 978-0-340-983-546.
Munro KI, Horne AW, Critchley HOD. Amenorrhoea, oligomenorrhoea and hypogonadal-pituitary function. In Gynaecology, 4th Edition. Eds Shaw, Luesly, Monga. Churchill Livingston 2010 ISBN: 978-0-7020-3120-5.
Maybin J, Horne AW, Critchley HOD. ‘Menstrual Disorders’ and ‘Benign Gynaecological Disorders’. In Training in Obstetrics and Gynaecology; the essential curriculum, 1st Edition. Eds Sarris, Saxena, Bewley. Oxford University Press 2009 ISBN 978-0-19-921847-9.
